Tuesday, July 9, 2013

07/07 Padres Preview: Game 89 @ Washington

The Padres will send the young lefty Robbie Erlin to the hill to go up against San Diego native Stephen Strasburg.

This Padres road trip started out promising with a win over the Marlins on June 28th. Since then, they've dropped eight straight games. Today in the 10th and final game of the trip, the Friars will get one last chance for a win before returning home to San Diego. Two young pitchers will battle it out on the mound in the finale at Nationals Park.

Rookie southpaw Robbie Erlin will get the ball for the Padres in his fourth career start. He ran into trouble his last time out when he was tagged for three runs and failed to escape the fourth inning. He faces the Nationals for the first time today as he tries to break San Diego out of their longest losing streak in two years.

The Padres offense has stepped up the production these past two games, but has been otherwise stymied by pitching on the road during their losing streak. After combining for seven total runs over the first six of their eight-game skid, they scored eleven in the first two games in Washington. Despite that, however, they still struggled to get runs home when they really needed to, hitting just 3-for-23 with runners in scoring position.

Today they'll face San Diego's own Stephen Strasburg, who despite his 4-6 record this season has been throwing the ball very well. He has a 1.29 ERA over his last nine starts and a 2.24 ERA on the year. He's already been tested against the Padres this season, giving up two runs (one earned) on three hits in eight innings of work back in May at Petco Park.

Strasburg's bane this season has been a lack of run support. Over his last four starts (of which the Nationals have gone 1-3), he's gotten just four total runs of support from his offense. In his most recent outing, he held the Brewers to three hits while striking out eight in seven shutout innings, but his bullpen gave up four runs and the Nats couldn't put a single run on the board, meaning a no-decision for Strasburg.

The Padres dropped back into the NL West cellar after yesterday's loss and now sit 6 1/2 games out of first place. They really need this win to stay afloat and help them get back on track here in the second half of the season.

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Source: http://www.gaslampball.com/2013/7/7/4500464/07-07-padres-preview-game-89-washington

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Sunday, July 7, 2013

US economy adds 195K jobs; unemployment 7.6 pct.

In this Monday, June 24, 2013, photo, a job seeker gets her resume critiqued at a career fair, in King of Prussia, Pa. U.S. employers added a robust 195,000 jobs in June and many more in April and May than previously thought. The job growth raises hopes for a stronger economy in the second half of 2013. (AP Photo/Matt Slocum)

In this Monday, June 24, 2013, photo, a job seeker gets her resume critiqued at a career fair, in King of Prussia, Pa. U.S. employers added a robust 195,000 jobs in June and many more in April and May than previously thought. The job growth raises hopes for a stronger economy in the second half of 2013. (AP Photo/Matt Slocum)

In this June 21, 2013 photograph a sign seeking drivers is posted outside the Pearl, Miss., customer service center for Central Transport, a long haul transport trucking company. U.S. employers added a robust 195,000 jobs in June and many more in April and May than previously thought. The job growth raises hopes for a stronger economy in the second half of 2013. (AP Photo/Rogelio V. Solis)

(AP) ? U.S. employers are sending a message of confidence in the economy ? hiring more workers, raising pay and making the job market appear strong enough for the Federal Reserve to slow its bond purchases as early as September.

The economy gained a robust 195,000 jobs in June and many more in April and May than previously thought. The unemployment rate remained 7.6 percent in June because more people started looking for jobs ? a healthy sign ? and some didn't find them. The government doesn't count people as unemployed unless they're looking for work.

The Labor Department's report Friday pointed to a U.S. job market that's showing surprising resilience in the face of tax increases, federal spending cuts and economic weakness overseas. Employers have added an average 202,000 jobs for the past six months, up from 180,000 in the previous six.

The job growth is being fueled in part by consumer spending and the housing recovery. Consumer confidence has reached a 5? year high and is helping drive up sales of homes and cars. Hiring was especially strong in June among retailers, hotels, restaurants, construction companies and financial services firms.

"The numbers that we're seeing are more sustainable than we thought," said Paul Edelstein, U.S. economist at IHS Global Insight, a forecasting firm. "We're seeing better job numbers, the stock market is increasing and home prices are rising."

Average pay also rose sharply last month. It's exceeded inflation this year after barely keeping pace since the Great Recession ended four years ago. Average hourly pay rose 10 cents in June to $24.01. Over the past 12 months, it's risen 2.2 percent. Over the same period, consumer prices have increased 1.4 percent.

Stocks closed sharply higher Friday. The Dow Jones industrial average surged 147 points, nearly 1 percent. The yield on the 10-year Treasury note jumped from 2.56 percent to 2.73 percent, its highest level since August 2011. That's a sign that investors think the economy is improving.

Among the employers benefiting from Americans' continued willingness to spend is Carlisle Wide Plank Floors, based in Stoddard, N.H. Carlisle makes hardwood flooring used in stores, restaurants and hotels. CEO Michael Stanek said orders jumped 30 percent in the first quarter compared with a year earlier.

The company is hiring factory, sales and administrative employees to meet the higher demand. Carlisle expects to add about 15 employees this year to its 85-person workforce.

Friday's report showed that the U.S. economy added 70,000 more jobs in April and May than the government had previously estimated ? 50,000 in April and 20,000 in May.

Further job growth could lower unemployment and help the economy rebound after a weak start this year. If so, the Fed would likely scale back its bond purchases later this year.

The Fed has been buying $85 billion in Treasury and mortgage bonds each month since late last year. The purchases pushed long-term interest rates to historic lows, fueled a stock rally and encouraged consumers and businesses to borrow and spend. The low rates have helped support an economy that's had to absorb government spending cuts and a Social Security tax increase that's shrunk paychecks this year.

John Silvia, chief economist at Wells Fargo, said he thinks the Fed will announce at its September policy meeting that it will start reducing its bond purchases, perhaps to $75 billion a month.

Chairman Ben Bernanke has said the Fed's bond buying could end around the time unemployment reaches 7 percent. The Fed foresees that happening around mid-2014. But Silvia said he didn't think unemployment would reach 7 percent by then. He thinks the Fed could continue its bond buying into 2015.

Friday's report contained at least one element of concern: Many of the job gains were in generally lower-paying industries, a trend that emerged earlier this year. The hotels, restaurants and entertainment industry added 75,000 jobs in June. This industry has added an average 55,000 jobs a month this year, nearly double its average in 2012. Retailers added 37,000. Temporary jobs rose 10,000.

The health care industry added 20,000 jobs, construction 13,000. But manufacturing, which includes many higher-paying positions, shed 6,000. The manufacturing sector has weakened this year.

Many of the new jobs are only part time. The number of Americans who said they were working part time but would prefer full-time work jumped 322,000 to 8.2 million ? the most in eight months.

That could be a sign that some employers are hiring more part-time workers to avoid the health care reform law's requirement that companies provide health coverage to full-time staff. That mandate was to take effect Jan. 1. But this week, the Obama administration postponed it until 2015.

The rise in part-time jobs helped boost one measure of weakness in the job market ? the so-called underemployment rate. This includes not only the unemployed but also people with part-time jobs who want full-time work and people who have stopped looking for work.

In June, the underemployment rate rose from 13.8 percent to 14.3 percent. That's still down from 14.8 percent a year ago. The rate peaked at 17.1 percent in April 2010.

Jobs have been added at a faster pace this year than the economy's sluggish growth would suggest. The economy expanded at only a 1.8 percent annual rate in the first three months of the year. Most analysts think it grew even more slowly in the April-June quarter.

But later this month, the government will revise its estimate of the economy's growth for the first quarter, and many analysts think it will be revised up. They also think the economy will accelerate in the second half of the year.

Last month's job growth came solely from the private sector, particularly services firms. Government jobs fell 7,000, mostly at the federal level. The federal government has shed 65,000 jobs in the past 12 months. Some of that decline is due to the spending cuts that kicked in March 1.

Declining government employment has been a drag on the job market since the recession officially ended in June 2009. In a typical recovery, governments add at least 20,000 jobs a month.

Solid hiring in the private sector is lifting wages, even in some lower-paying industries. Average hourly pay for retail employees, for example, rose 6 cents in June to $16.64, and is up nearly 2 percent in the past year.

The overall increase in pay is "the standout feature of this report," said Ryan Sweet, an economist at Moody's Analytics. Low inflation rate is also helping consumers, he noted.

"The tide is continuing to turn for the consumer," Sweet said. "The consumer is going to continue to be able to shoulder this recovery."

June's 7.6 percent unemployment rate is derived from a survey of households, which found that 177,000 more people started looking for jobs last month. Most found them. The rise in job seekers suggests that Americans think their prospects have brightened. Because some job seekers didn't find work right away, the number of unemployed was largely unchanged at 11.8 million.

The job gain for the month is calculated from a separate survey of employers.

The percentage of Americans either working or actively looking for work rose for a second straight month to 63.5 percent. This is called the "labor force participation rate." The participation rate has been generally declining since peaking at 67.3 percent in 2000. That's partly the result of baby boomers retiring and leaving the workforce.

___

AP Business Writer Martin Crutsinger contributed to this report.

___

Follow Chris Rugaber on Twitter at http://Twitter.com/ChrisRugaber

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-07-05-US-Economy/id-c691637aa949459c8ebfd1dd290bb01c

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Saturday, July 6, 2013

Epic hiring for "unannounced competitive online action game ...

Epic Games logo

Epic Games are up to something. More specifically, they?re hiring some new people to get up to something; and that something is described as an ?unannounced competitive online action game.? I know, I know, that sounds like it could just be more?Gears of War, but wait there?s more.

The job posting also mentions ?player progression? (levelling up,) ?heavy itemization? (microtransactions) and a ?dynamic economy? (more microtransactions.) Exciting! Sounds kind of action-RPG-ey and also kind of MMO-ey. Not surprising, since the theme of this year?s E3 was putting every single game into some sort of hop-in, hop-out dynamic online multiplayer box.

If you want the gig, you?ll need ?Demonstrated experience with advancement, itemization and progression based systems? and ?Experience with competitive multiplayer balance.?

Not a great deal to go on there, admittedly. It sounds rather early in development, whatever it is. Epic has quite a few interesting licenses stashed away from their ?Epic Megagames? era, so it could be one of those. Jill of the Jungle revival, your time is (probably not) now.

Source: Neogaf

NEW THIS WEEK - READ NOW!

Source: http://www.incgamers.com/2013/07/epic-hiring-for-unannounced-competitive-online-action-game

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Friday, July 5, 2013

New research could pave the way to safer treatments for arthritis

New research could pave the way to safer treatments for arthritis [ Back to EurekAlert! ] Public release date: 4-Jul-2013
[ | E-mail | Share Share ]

Contact: Gilead Amit
gda07@imperial.ac.uk
Imperial College London

The increased risk of heart attack or stroke associated with many arthritis drugs may be avoidable, according to a new international study co-authored by researchers at Imperial College London.

Drugs such as Vioxx, diclofenac, ibuprofen and Celebrex operate by blocking an enzyme known as COX-2, whose presence in blood vessels has up until now been held responsible for these side effects. New research carried out on mice has revealed that COX-2 is largely absent from the major blood vessels and instead found in the brain, gut, and kidney as well as the thymus gland in the chest.

Now that researchers know where in the body the drug is acting, they can begin to develop safer, more targeted drugs for patients with arthritis as well as cancer.

Arthritis drugs have long been associated with potentially fatal cardiovascular side-effects in patients. Health concerns led to the anti-inflammatory Vioxx being withdrawn from the market in 2004, and this week medical regulators have advised some patients to stop using the painkiller diclofenac.

Researchers have always believed that COX-2 was found in the blood vessels where it was central to preventing the formation of clots. This meant that any drug that inhibited the enzyme was thought to lead to an increased risk of clotting.

The new study, published today in the journal PLOS ONE, reveals that COX-2 is largely absent from the major blood vessels. Instead COX-2 appears to be present in the brain, kidney, thymus and gut, where it may well be affecting the cardiovascular health.

Lead author, Professor Jane Mitchell of Imperial's Faculty of Medicine said: "Now we know the true sites of COX-2, we can begin to develop new ideas that will lead to better drugs for arthritis and cancer with fewer side effects."

The new research suggests future development of COX-2 inhibitors that carry reduced risk of stroke or heart attack may be possible. Professor Mitchell added: "This study does not provide all the answers, but once we understand exactly how COX-2 affects the cardiovascular system we will be in a position to design new therapies. This will not be easy but all the tools are available and we could be looking at new leads within five to ten years."

In order to accurately measure concentrations of COX-2 within the body, the researchers used mice whose COX-2 gene had been replaced with a gene called luciferase, which gives fireflies their distinctive glow. This allowed researchers to create detailed images of the distribution of COX-2 throughout the body.

Professor Anna Nicolaou, a co-author, now at the University of Manchester, said: "This study is the first to use such sophisticated techniques to determine the locations of COX-2 within the body. The use of mass spectrometry and genetically modified mice in this way represents a significant advance in the field."

This was echoed by Professor Tim Warner, a co-author from Queen Mary, University of London, who said: "These cutting edge techniques are at last supplying us with the definitive answers we need to understand the side effects of arthritis drugs. This could help improve therapy for many millions of patients worldwide."

###

The research was funded by the Wellcome Trust.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New research could pave the way to safer treatments for arthritis [ Back to EurekAlert! ] Public release date: 4-Jul-2013
[ | E-mail | Share Share ]

Contact: Gilead Amit
gda07@imperial.ac.uk
Imperial College London

The increased risk of heart attack or stroke associated with many arthritis drugs may be avoidable, according to a new international study co-authored by researchers at Imperial College London.

Drugs such as Vioxx, diclofenac, ibuprofen and Celebrex operate by blocking an enzyme known as COX-2, whose presence in blood vessels has up until now been held responsible for these side effects. New research carried out on mice has revealed that COX-2 is largely absent from the major blood vessels and instead found in the brain, gut, and kidney as well as the thymus gland in the chest.

Now that researchers know where in the body the drug is acting, they can begin to develop safer, more targeted drugs for patients with arthritis as well as cancer.

Arthritis drugs have long been associated with potentially fatal cardiovascular side-effects in patients. Health concerns led to the anti-inflammatory Vioxx being withdrawn from the market in 2004, and this week medical regulators have advised some patients to stop using the painkiller diclofenac.

Researchers have always believed that COX-2 was found in the blood vessels where it was central to preventing the formation of clots. This meant that any drug that inhibited the enzyme was thought to lead to an increased risk of clotting.

The new study, published today in the journal PLOS ONE, reveals that COX-2 is largely absent from the major blood vessels. Instead COX-2 appears to be present in the brain, kidney, thymus and gut, where it may well be affecting the cardiovascular health.

Lead author, Professor Jane Mitchell of Imperial's Faculty of Medicine said: "Now we know the true sites of COX-2, we can begin to develop new ideas that will lead to better drugs for arthritis and cancer with fewer side effects."

The new research suggests future development of COX-2 inhibitors that carry reduced risk of stroke or heart attack may be possible. Professor Mitchell added: "This study does not provide all the answers, but once we understand exactly how COX-2 affects the cardiovascular system we will be in a position to design new therapies. This will not be easy but all the tools are available and we could be looking at new leads within five to ten years."

In order to accurately measure concentrations of COX-2 within the body, the researchers used mice whose COX-2 gene had been replaced with a gene called luciferase, which gives fireflies their distinctive glow. This allowed researchers to create detailed images of the distribution of COX-2 throughout the body.

Professor Anna Nicolaou, a co-author, now at the University of Manchester, said: "This study is the first to use such sophisticated techniques to determine the locations of COX-2 within the body. The use of mass spectrometry and genetically modified mice in this way represents a significant advance in the field."

This was echoed by Professor Tim Warner, a co-author from Queen Mary, University of London, who said: "These cutting edge techniques are at last supplying us with the definitive answers we need to understand the side effects of arthritis drugs. This could help improve therapy for many millions of patients worldwide."

###

The research was funded by the Wellcome Trust.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-07/icl-nrc070313.php

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Thursday, July 4, 2013

Vine update brings new tools and channels, videos still six seconds long

Image

Vine's offering up the latest update to the iOS version of the video sharing app. Nope, it's not an Instagram-inspired lengthening. Instead, version 1.3 brings a handful of new tools to the micro-video service, assuring that you make the best six second film possible, including grid, focus and ghost. The app's also adding 15 new content channels like music, nature and comedy, each of which has its own distinct theme and Popular feed. Revining, meanwhile, makes it easier to share friends' videos and On The Rise, shows you up and coming Viners. Also new is protected posts, so you don't have to let the whole world in on your video brilliance, if you're the shy sort.

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Source: Vine Blog

Source: http://www.engadget.com/2013/07/03/vine-update/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Tuesday, July 2, 2013

Altitude sickness may hinder ethnic integration in the world's highest places

July 1, 2013 ? Ethnic segregation in nations straddling the world's steepest terrains may be reinforced by the biological tolerance different peoples have to altitude, according to one of the first studies to examine the effect of elevation on ethnic demographics.

Research from Princeton University published in the journal Applied Geography suggests that people native to low-lying areas can be naturally barred from regions such as the Tibetan Plateau, the Andes or the Himalayas by altitude sickness, which is caused by low oxygen concentration in the air and can be life-threatening. As a result, the homogeny of the local population can increase with elevation. In nations shared by people of high- and lowland extractions, this separation can potentially increase ethnic tension.

The researchers studied Tibet and found that elevation has heavily influenced the location of the surrounding region's population of Han Chinese, who make up 92 percent of China's population and originate from the country's eastern plains. Tibet has an average elevation of roughly 14,370 feet (4,380 meters) above sea level. The number of settlements with a large Han Chinese population peaks at around 8,900 feet (2,700 meters), while Tibetan settlements only begin to peter out beyond 17,000 feet (5,200 meters), the researchers found. The researchers attribute the sudden drop in the Han Chinese population to altitude sickness, and cite existing research showing that Han Chinese are indeed susceptible to altitude sickness in areas in which Tibetans thrive.

First author Christopher Paik, who undertook the study as a postdoctoral research scholar in the Empirical Studies of Conflict Project in Princeton's Woodrow Wilson School of Public and International Affairs, said that the research adds a new dimension to the study of how terrain influences demographic patterns. The field already explores the role of factors such as soil quality and access to the sea. The biological effects of elevation make altitude a particularly objective and reliable measurement for helping determine and understand how populations around the world's highest areas form, he said.

"There is very little research about the effect of altitude on migration patterns," said Paik, who is now an assistant professor of politics at New York University Abu Dhabi. "One of the nice things about using this geographical indicator as an independent variable is that there isn't any human intervention in determining the altitude of the region because it's established by nature.

"Rather than saying there is merely a correlation between settlement patterns and altitude, our research takes it one step further and suggests that altitude can directly determine the settlement patterns we see today. There's a causal story here," Paik said.

The separation that results from these settlement patterns could result in greater ethnic friction, Paik said. He initiated the current study in the wake of the 2008 unrest in Tibet, a series of protests that lead to imprisonment, detainment and clashes with Chinese security forces. Paik noticed that the most violent outbreaks occurred in areas of Tibet with the lowest relative concentrations of Han Chinese -- regions that also have the highest elevations. (Paik is currently working on a paper that correlates lower levels of violence during the 2008 unrest with lower elevation and greater Tibetan/Han integration.)

Paik and co-author Tsering Shawa, who heads the Digital Map and Geospatial Information Center in Princeton's Lewis Library, used 2000 Chinese census data to determine the Han population in settlements within the traditional Tibetan homeland, which includes the Tibetan Autonomous Region as well as portions of the Chinese provinces Qinghai, Gansu, Sichuan and Yunnan. They also gauged past Han Chinese presence through maps and a database developed by Shawa that indicate whether the official name of the 1,960 settlements in this area is Han Chinese, Tibetan or both.

The researchers found a similar distribution pattern of towns where at least one-third of the population are Han Chinese and traditional Han settlements (most of which date as far back as the 13th century) -- the bulk are located lower than 8,900 feet above sea level. No towns with a Chinese name exist above 15,000 feet (4,600 meters). Meanwhile, the greatest number of settlements with a Tibetan name stands at an only slightly lower elevation of 14,760 feet (4,500 meters), an area that the census shows has a minimum of Han Chinese inhabitants.

"What the outcome suggests is that there is a direct effect of altitude now as well as in historical settlement patterns," Paik said. "On the one hand there are settlements where Han Chinese came 1,000 years ago and established roots in that region, which makes it easier for migrants to come in. That provides a channel through which more Chinese live there today because their ancestors lived there as well.

"But if historical settlement is the only channel through which altitude influenced current settlement patterns, then there wouldn't be the direct influence of elevation through altitude sickness that we still see," Paik said. "Han Chinese still suffer from altitude sickness and the influence on settlement seems to persist today."

Paik and Shawa reference at least 10 studies that delve into the genetic adaption of Tibetans' blood cells and lung tissue to the low-oxygen conditions of a life on high -- a tolerance research suggests they share with Andes dwellers in countries such as Bolivia.

Han Chinese do not enjoy this predisposition even in modern times. The researchers cite a 2009 paper in the journal Clinica Chimica Acta that explored the genetic susceptibility of Han Chinese laborers to the pulmonary edema -- potentially fatal fluid buildup in the lungs -- they experienced during construction of the Qinghai-Tibet railway completed in 2005.

"The main contribution of this research is to point out geography does matter in ethnic demographic patterns," said Enze Han, an assistant professor of politics and international studies at the University of London. Han, who had no role in the research but is familiar with it, agrees with the researchers when they write that modern technology and transportation makes migration into high-altitude lands easier.

But, Paik said, the population distributions he and Shawa document show that geography -- via altitude sickness -- continues to play a strong role in regional diversity despite modern trappings such as the Qinghai-Tibet railway and government initiatives such as China's Western Development Program.

"Ethnic integration policy seems to work in the long run, but it will be harder to implement in the higher altitude regions," Paik said. "There seems to be a strong enough influence of altitude on settlement patterns such that even if you try to have integration happening there, nature works against those initiatives."

This work was supported by a grant from the Air Force Office of Scientific Research (AFOSR) award number FA9550-09-1-0314.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/9ZTFe8CoK9Q/130701151830.htm

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Museum Helps Preserve Iconic Tortoise Lonesome George

Museum Helps Preserve Iconic Tortoise Lonesome George

Lonesome George, the world-famous Pinta Island tortoise who was the last of his kind when he died in June 2012, will be preserved in consultation with scientists from the American Museum of Natural History and by the same expert taxidermy and conservation team that worked on the acclaimed renovation of the Museum's Bernard Family Hall of North American Mammals.

Image: Zachary Grinspan

An icon for biodiversity conservation, Lonesome George will be on display at the Museum for a limited time starting this winter before he is returned to the Gal?pagos. As reported today in The New York Times, the Museum is working closely with the Gal?pagos National Park Service, SUNY College of Environmental Sciences and Forestry, and the Gal?pagos Conservancy to prepare Lonesome George?s body and spread awareness of the importance of conservation.

Learn more about Lonesome George and his preservation in this video:

Source: http://kinja.amnh.org/museum-helps-preserve-iconic-tortoise-lonesome-george-608812329

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